生态学

赵凯

发布时间:2024-01-03 作者: 浏览量:

赵凯,1973年12月,二级教授,台州学院纳米生物材料与免疫学创新团队首席科学家、生命科学学院院长、生物与医药专业硕士学位培育点负责人、台州市生物医药与高端剂型重点实验室主任

学习经历

2001/09 – 2004/07,东北农业大学,食品科学与技术学院,博士

1998/09 – 2001/07,东北农业大学,动物医学院,硕士

1994/09 – 1998/07,黑龙江八一农垦大学,动物科技学院,学士

工作经历

2021/04 – 至今,台州学院,高等研究院/生命科学学院,教授

2021/04 – 至今,皇冠真人注册(China)官方网站,生命科学学院兼职教授

2016/12 – 2018/01,University of Florida,访问学者

2009/09 – 2021/04,皇冠真人注册(China)官方网站,生命科学学院,教授

2006/09 – 2009/08,皇冠真人注册(China)官方网站,生命科学学院,副教授

2004/12 – 2007/02,中国农业科学院哈尔滨兽医研究所,博士后

2004/07 – 2006/08,皇冠真人注册(China)官方网站,生命科学学院,讲师

研究方向

肠道微生物菌群与肠道免疫、微生态制剂与替抗新产品、疫苗/药物递送系统、动物疫苗、药物高端制剂、检测新试剂

代表作

发表学术论文(部分):

(1)Yinzhuo Xie, Wei Xu, Zheng Jin,Kai Zhao*. Chondroitin sulfate functionalized palmitic acid and cysteine cografted-quaternized chitosan for CD44 and gut microbiota dual-targeted delivery of curcumin. Materials Today Bio. 2023,20: 100617.(SCI IF8.2

(2)Yinzhuo Xie, Zheng Jin, Da Ma, Tan Hui Yin,Kai Zhao*. Palmitic acid- and cysteine-functionalized nanoparticles overcome mucus and epithelial barrier for oral delivery of drug. Bioengineering & Translational Medicine. 2023,e10510.(SCI IF7.4

(3)Zhi Zhao, Yue Peng, Xueao Shi,Kai Zhao*. Chitosan derivative composite nanoparticles as adjuvants enhance the cellular immune responseviaactivation of the cGAS-STING pathway. International Journal of Pharmaceutics. 2023,636: 122847.(SCI IF5.8

(4)Shangen Xu, Lu Yu, Qiaoyang Teng, Xuesong Li, Zheng Jin, Yang Qu, Jiawei Li, Qihong Zhang, Zejun Li *,Kai Zhao*.Enhance immune response to H9 AIV DNA vaccine based on polygene expression and DGL nanoparticle encapsulation.Poultry Science.2023,102: 102925.(SCI IF4.4

(5)Shangen Xu, Hailing Lan, Qiaoyang Teng, Xuesong Li, Zheng Jin, Yang Qu, Jiawei Li,Qihong Zhang, Hong Kang, Tan Hui Yin, Zejun Li*,Kai Zhao*.An immune-enhanced multivalent DNA nanovaccine to prevent H7 and H9 avian influenza virus in mice.International Journal of Biological Macromolecules.2023, 251: 126286.(SCI IF8.2

(6)Yiyu Wang, Xinyu Wang, Xingxun Liu, Chunqing Niu, Guiting Yu, Yuanjing Hou, Chao Hu,Kai Zhao*, Jian Shi*. Fabrication, characterization and potential application of biodegradable polydopamine-modified scaffolds based on natural macromolecules.International Journal of Biological Macromolecules.2023, .(SCI IF8.2

(7)JialiLiu,SihanGuo,ZhengJin,KaiZhao.Adjuvanted quaternized chitosan composite aluminum nanoparticles-based vaccine formulation promotes immune responses in chickens. Vaccine. 2023, 41: 2982-2989.(SCI IF4.169

(8)Guiting Yu, Chunqing Niu, Jiali Liu, Jue Wu, Zheng Jin*, Yiyu Wang*, Kai Zhao*.Preparation and properties of self-crosslinking hydrogels based on chitosan derivatives and oxidized sodium alginate.ACS Omega. ACS Omega.2023,8: 19752-19766.(SCI IF4.1

(9)Jue Wu, Qian Chen, Wenfei Wang, Yuhong Lin, HongKang, Zheng Jin*,Kai Zhao*.Chitosanderivative-basedmicrospheresloaded withfibroblastgrowthfactor for thetreatment ofdiabetes.Polymers.2023, 15:3099.(SCI IF5.0

(10)Chen Zhang,Zheng Jin*,Yuhong lin,Yiyu Wang,Kai Zhao*.Functionalized N-hydroxypropyl trimethylammonium chloride chitosan as an ICG/DOX co-delivery nanocarriers for targetedand chemo-photothermal combination therapy.Journal of Drug Delivery Science and Technology. 2023, 88: 104920.(SCI IF5.0

(11)Zheng Jin, Gaowei Hu,Kai Zhao*. Mannose-anchored quaternized chitosan/thiolated carboxymethyl chitosan composite NPs as mucoadhesive carrier for drug delivery. Carbohydrate Polymers. 2022, 283: 119174.(SCI IF 11.2

(12)Yuhong Lin, Beini Sun, Zheng Jin,Kai Zhao*.Enhanced immune responses to mucosa by functionalized chitosan-based composite nanoparticle as vaccine adjuvant for intranasal delivery.ACS Applied Materials & Interfaces. 2022,14:52691-52701.(SCI IF9.5

(13)Yuan Gao, Xiaochen Gong, Shuang Yu, Zheng Jin, Qicheng Rua, Chunjing Zhang,Kai Zhao*.Immune enhancement ofN-2-Hydroxypropyl trimethyl ammonium chloride chitosan/carboxymethyl chitosan nanoparticles vaccine.International Journal of Biological Macromolecules. 2022, 220: 183-192.(SCI IF8.2

(14)Zhi Zhao, Jinyu Han, Shangen Xu, Zheng Jin, Tan Hui Yin,Kai Zhao*.Amoxicillin encapsulated in theN-2-Hydroxypropyl trimethyl ammonium chloride chitosan andN,O-carboxymethyl chitosan nanoparticles: Preparation, characterization, and antibacterial activity.International Journal of Biological Macromolecules. 2022, 221: 613-622.(SCI IF8.2

(15)Yinzhuo Xie, Xiaochen Gong, Zheng Jin, Wei Xu,Kai Zhao*.Curcumin encapsulation in self-assembled nanoparticles based on amphiphilic palmiticacid-grafted-quaternized chitosan with enhanced cytotoxic, antimicrobial and antioxidant properties.International Journal of Biological Macromolecules.2022, 222: 2855-2867.(SCI IF8.2

出版著作及教材:

(1)赵凯、曹宏伟著.新城疫纳米缓释疫苗的研制及其免疫效果.科学普及出版社,ISBN 978-7-110-08370-5,2014.8

(2)赵凯著.紫杉醇高产菌株的选育及其生物合成的调控.中国科学技术出版社,26.6万字,ISBN 978-7-5046-5165-5,2009.1

(3)赵凯参编著.动物基因工程疫苗原理与方法.化学工业出版社,ISBN 978-7-122-04824-0,2009.5

科研获奖:

(1)赵凯(1).新城疫疫苗生物降解微胶囊缓释剂和耐热冻干保护剂的研制及应用,黑龙江省人民政府,黑龙江省科学技术奖(技术发明),一等奖,2014.8

(2)赵凯(1).可降解生物材料合成及其在兽用疫苗中的应用,黑龙江省人民政府,黑龙江省科学技术奖(自然科学),二等奖,2013.11

主持科研项目(部分):

(1)国家自然科学基金面上项目,《mRNA疫苗递送系统的构建及其增强猪肠道粘膜免疫应答作用机制的研究》(32370987),2024.1-2027.12,50万元,主持。

(2)国家自然科学基金面上项目,《壳聚糖季铵盐水凝胶激活I3K和ERK1/2通路调控VEGF分泌促进血管新生的分子机制解析》(32170844),2022.1-2025.12,58万元,主持。

(3)国家自然科学基金面上项目,《N-2-羟丙基三甲基氯化铵壳聚糖-N, O-羧甲基壳聚糖为佐剂制备H9N2禽流感病毒基因纳米疫苗经黏膜递送的效果及机制》(31771000),2018.01-2021.12,72万元,主持。

(4)国家自然科学基金面上项目,《N-2-羟丙基二甲基乙基氯化铵壳聚糖/N,O-羧甲基壳聚糖纳米粒新城疫疫苗的制备及免疫作用机制研究》(31570929),2016.01-2019.12,72万元,主持。

(5)国家自然科学基金面上项目,《新城疫DNA疫苗三甲基壳聚糖纳米粒黏膜免疫传递系统的构建及其免疫作用机制研究》(31072119),2011.1-2013.12,33万元,主持。

(6)国家重点研发计划,《以LDH@SiO2为递送载体研发新城疫缓释纳米疫苗》(2017YFD0500706),2017.07-2020.12,55万元,主持。

(7)国家重点研发计划项目,《以改性多糖为佐剂制备猪流行性腹泻缓释纳米疫苗》(2017YFD0500603),2017.07-2020.12,58万元,主持。

(8)国家科技部国际科技合作专项,《猪支原体肺炎灭活疫苗技术合作开发》(2012DFA30250),2012.5-2015.12,30万元,主持。

(9)教育部科学技术研究重点项目,《新城疫N-2-羟丙基三甲基氯化铵壳聚糖纳米粒DNA疫苗制备及免疫作用机制研究》(212048),2012.1-2014.12,10万元,主持。

(10)浙江省科技计划项目-重点研发计划项目,《安全高效生物兽药研发—防控猪重要病毒性疫病的安全高效兽药检测新试剂研发》(2022C02031),2022.1至2024.12,1200万元,主持。